Research Articles
Field Desorption Mass Spectrometry of Azathioprine and its Metabolites

https://doi.org/10.1002/jps.2600630907Get rights and content

Abstract

The field desorption mass spectra of azathioprine, I, and some of its metabolites, II–IV, were investigated and compared to their electron impact spectra. The field desorption spectra were shown to be especially well suited for the determination of molecular weights in drug metabolism studies of drugs conjugated with amino acids and peptides. This technique was applied to a metabolite of azathioprine isolated from rat urine and proved to be useful.

References (17)

  • BeckeyH.D.

    Int. J. Mass Spectrom. Ion Phys.

    (1969)
  • WinklerH.U. et al.

    Biochem. Biophys. Res. Commun.

    (1972)
  • BrentD.A. et al.

    Tetrahedron Lett.

    (1973)
  • SchultenH.R. et al.

    Tetrahedron

    (1973)
  • ElionG.B. et al.

    Cancer Chemother. Rep.

    (1961)
  • ElionG.B. et al.

    Cancer Res.

    (1963)
  • de MirandaP. et al.

    J. Pharmacol. Exp. Ther.

    (1973)
  • ChalmersA.H. et al.

    Aust. J. Exp. Biol. Med. Sci.

    (1967)
There are more references available in the full text version of this article.

Cited by (22)

  • Azathioprine

    1981, Analytical Profiles of Drug Substances and Excipients
View all citing articles on Scopus
View full text