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Potential Utility of Recombinant Human GM-CSF as Adjunctive Treatment of Refractory Oropharyngeal Candidiasis in AIDS Patients

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Abstract

 The aim of the study was to investigate the use of granulocyte macrophage-colony stimulating factor (GM-CSF) as an adjunctive treatment for clinically refractory mucosal candidiasis in patients with advanced AIDS. Three patients with advanced AIDS and oropharyngeal candidiasis clinically refractory to azoles or amphotericin B received GM-CSF for 14 days along with either fluconazole or amphotericin B. All three patients showed clinical improvement and mycological improvement without any adverse events. Thus, GM-CSF may be a possible alternative as adjunctive therapy in the management of refractory mucosal candidiasis in patients with advanced AIDS.

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Authors and Affiliations

  1. Division of Infectious Diseases/Department of Internal Medicine, Wayne State University School of Medicine, 3990 John R, 4-yellow center, Detroit, Michigan 48201, USA, , , , , , US

    J. A. Vazquez, S. Gupta & A. Villanueva

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  1. J. A. Vazquez
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  2. S. Gupta
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  3. A. Villanueva
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Vazquez, J., Gupta, S. & Villanueva, A. Potential Utility of Recombinant Human GM-CSF as Adjunctive Treatment of Refractory Oropharyngeal Candidiasis in AIDS Patients. EJCMID 17, 781–783 (1998). https://doi.org/10.1007/s100960050185

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  • DOI: https://doi.org/10.1007/s100960050185

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