Abstract
We investigated seasonal changes in blood concentrations of interleukin-6 (IL-6), adrenocorticotrophic hormone (ACTH), metabolites of catecholamine (VMA, HVA, and 5-HIAA) and cortisol in humans. Eight volunteers were investigated at four times during the year (February, May, August and October) at latitude 35° N. The mean ambient temperature at the collection periods was higher in the order of summer > autumn ≈ spring > winter. Changes in mood were also monitored by a profile of mood states (POMS) questionnaire. The concentration of IL-6 was significantly higher in winter and summer than in spring and autumn. The concentrations of ACTH, HVA and VMA were significantly higher in summer. No seasonal variation was detected in cortisol. There were significant differences among the seasons in subscale tension and anger in the POMS questionnaire; the tension subscale showed significant differences between spring and autumn, with a higher score in spring. The results demonstrate that Il-6, ACTH, HVA and VMA exhibit statistically significant seasonal rhythms, which might have important diagnostic and therapeutic implications.
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Acknowledgements
We thank Jim Waterhouse (Liverpool John Moores University, UK) for constructive comments. This study was supported by a Grant-in-Aid for a JSPS Fellow (18.06719) from the Japan Society for the Promotion of Science. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
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Dominika Kanikowska is a JSPS Postdoctoral Fellowship scholar.
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Kanikowska, D., Sugenoya, J., Sato, M. et al. Seasonal variation in blood concentrations of interleukin-6, adrenocorticotrophic hormone, metabolites of catecholamine and cortisol in healthy volunteers. Int J Biometeorol 53, 479–485 (2009). https://doi.org/10.1007/s00484-009-0236-1
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DOI: https://doi.org/10.1007/s00484-009-0236-1