Review
Meta-analysis on protective effect of electroacupuncture at “Nèiguān” (
PC 6) in rats with reperfusion injury induced myocardial ischemia

https://doi.org/10.1016/S1003-5257(15)30063-5Get rights and content

Abstract

Objective

To systematically evaluate the protection effect of electroacupuncture at “Nèiguān” (

PC 6) on myocardial damage by means of evidence-based medicine.

Methods

Databases were retrieved by computer, while dissertation compilations and conference proceedings were searched manually. Data were analyzed statistically by using RevMan5.2 software.

Results

Twelve studies were enrolled. Compared with myocardial ischemia reperfusion injury model group,

the magnitude of ECG ST II segment elevation can be reduced by means of electroacupuncture at PC 6 (WMD= –73.95, 95%CI[–109.69, –38.20]) and the difference was statistically significant (P<0.0001);
the ATPase in myocardial cells can be increased by means of electroacupuncture at PC 6 (SMD=2.28, 95% CI [1.50, 3.07]) and the difference was statistically significant (P<0.00001);
the release of cTnT can be reduced by means of electroacupuncture at PC 6 (WMD= –2.69, 95%CI[–3.16, –2.22]) and the difference was statistically significant (P<0.00001);
the size of myocardial infarction can be reduced by means of electroacupuncture at PC 6 (WMD= –17.99, 95% CI [–19.88, –16.09]) and the difference was statistically significant (P<0.00001);
the release of CK can be reduced by means of electroacupuncture at PC 6 (WMD= –0.44, 95%CI[–0.61, –0.27]) and the difference was statistically significant (P<0.00001);
the release of CK-MB can be reduced by means of electroacupuncture at PC 6 (SMD=–2.85, 95%CI[–4.46, –1.24]) and the difference was statistically significant (P<0.001);
the release of LDH can be reduced by means of electroacupuncture at PC 6 (SMD=–2.97, 95%CI [–4.87, –1.07]) and the difference was statistically significant (P<0.01).

Conclusion

Based on the current experimental evidences, electroacupuncture at PC 6 has a higher protective effect on myocardium.

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  • Supported by Natural Science Foundation of China: 81403460; Hubei Provincial Education and Science “The 12th Five-Year Plan” Project: 2014B095

    1

    First author: YANG Hui-sheng (1991-), male, undergraduate student.

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