Abstract
The purpose of this study is to extend the spectral range of a differential method of infrared micro-spectroscopy in order to allow the accurate detection of nanoparticles of interest for biomedical applications. Among these, metal–organic framework (MOF) nanoparticles have attracted increasing interest due to their capacity to incorporate high drug payloads, biodegradability, and possibility of tailoring their surfaces by grafting specific ligands. However, MOF particle detection in biological media without grafting or incorporating fluorescent molecules is challenging. We took advantage here of the presence of the specific absorption bands of nanoscale MOFs in far infrared in order to individually discriminate them. Here we show that single MOF nanoparticles can be imaged with a spatial resolution of a few tens of nanometers.
© 2017 Optical Society of America
Full Article | PDF ArticleMore Like This
Le Zheng, Chen Wei, Hongrong Zhou, Fanxi Sun, Ang Gao, Dongsheng Wang, and Yong Liu
Opt. Express 30(8) 12409-12419 (2022)
Yueli Zhang, Lihe Yan, Yuren Li, Jinhai Si, Wenjiang Tan, and Xun Hou
Opt. Mater. Express 13(2) 484-494 (2023)
Waed Ahmad, Cecile Coeur, Alexandre Tomas, Thomas Fagniez, Jean-Blaise Brubach, and Arnaud Cuisset
Appl. Opt. 56(11) E116-E122 (2017)