Abstract
A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG-b-PLLA/PDLA-CHOL) and poly(β-cyclodextrin) (PCD) with the molar ratios of CHOL/β-CD at 1:0.5, 1:1, and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/β-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.
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References
Ding, J., Shi, F., Li, D., Chen, L., Zhuang, X. and Chen, X., Biomater. Sci., 2013, 1(6): 633
Washington, K.E., Kularatne, R.N., Karmegam, V., Biewer, M.C. and Stefan, M.C., WIRES: Nanomed. Nanobiotechnol., 2017, 10.1002/wnan.1446
Liu, D.H., Ding, J.X., Xu, W.G., Song, X.F., Zhuang, X.L. and Chen, X.S., Acta Polymerica Sinica (in Chinese), 2014, (9): 1265
Tam, Y.T., Gao, J. and Kwon, G.S., J. Am. Chem. Soc., 2016, 138(28): 8674
Ding, J., Chen, L., Xiao, C., Chen, L., Zhuang, X. and Chen, X., Chem. Commun., 2014, 50(77): 11274
Kang, N., Perron, M.È., Prud'Homme, R.E., Zhang, Y., Gaucher, G. and Leroux, J.C., Nano Lett., 2005, 5(2): 315
Yang, L., Zhao, Z., Wei, J., El Ghzaoui, A. and Li, S., J. Colloid Interf. Sci., 2007, 314(2): 470
Ma, C., Pan, P., Shan, G., Bao, Y., Fujita, M. and Maeda, M., Langmuir, 2015, 31(4): 1527
Chen, L., Xie, Z., Hu, J., Chen, X. and Jing, X., J. Nanopart. Res., 2007, 9(5): 777
Heinzmann, C., Weder, C. and de Espinosa, L.M., Chem. Soc. Rev., 2016, 45(2): 342
Voorhaar, L. and Hoogenboom, R., Chem. Soc. Rev., 2016, 45(14): 4013
Xiao, C., Cheng, Y., Zhang, Y., Ding, J., He, C., Zhuang, X. and Chen, X., J. Polym. Sci., Part A: Polym. Chem., 2014, 52(5): 671
Jiang, Q., Zhang, Y., Zhuo, R. and Jiang, X., Colloid Surface B, 2016, 147: 25
Guan, B.Y., Yu, L. and Lou, X.W., Adv. Mater., 2016, 28(43): 9596
Zhang, Y., Xiao, C., Li, M., Chen, J., Ding, J., He, C., Zhuang, X. and Chen, X., Macromol. Biosci., 2013, 13(5): 584
Umezaki, Y., Iohara, D., Anraku, M., Ishitsuka, Y., Irie, T., Uekama, K. and Hirayama, F., Biomaterials, 2015, 45: 115
Kang, Y., Tang, X., Cai, Z. and Zhang, X., Adv. Funct. Mater., 2016, 26(48): 8920
Chen, L., Zhang, Z., Chen, X., Yao, X., He, C. and Chen, X., Acta Biomater., 2015, 18: 168
Rassu, G., Soddu, E., Cossu, M., Brundu, A., Cerri, G., Marchetti, N., Ferraro, L., Regan, R.F., Giunchedi, P., Gavini, E. and Dalpiaz, A., J. Control. Release, 2015, 201: 68
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This work was financially supported by the National Natural Science Foundation of China (Nos. 51673190, 51303174, 51603204 and 51390484).
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Feng, Xr., Ding, Jx., Gref, R. et al. Poly(β-cyclodextrin)-mediated polylactide-cholesterol stereocomplex micelles for controlled drug delivery. Chin J Polym Sci 35, 693–699 (2017). https://doi.org/10.1007/s10118-017-1932-7
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DOI: https://doi.org/10.1007/s10118-017-1932-7