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Serum haptoglobin concentrations are useful to confirm bovine respiratory disease (BRD) but several other parameters are not useful or need further research.
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Feed intake measurements, changes in cattle behavior, infrared thermography, and reticulorumen boluses have been successfully used for early disease detection.
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Prognostic methods using routinely collected treatment and cohort data at the time of treatment can be used to identify cattle at risk of unfavorable outcome.
Veterinary Clinics of North America: Food Animal Practice
A Systematic Review of Bovine Respiratory Disease Diagnosis Focused on Diagnostic Confirmation, Early Detection, and Prediction of Unfavorable Outcomes in Feedlot Cattle
Section snippets
Key points
Definitions for the Search
The systematic review included confirmation, early disease detection, and modalities to estimate post-therapeutic prognosis or predict unfavorable or fatal outcomes of BRD. Definitions for outcomes included in the review are as follows:
- 1.
The case definition of BRD in the included manuscripts has to be based on a minimum of clinical signs of respiratory disease and elevated rectal temperature (threshold varied among studies, but ≥39.5°C).
- 2.
Confirmatory tests are laboratory and other tests used to
Results and discussion
The literature search including evaluation of titles and abstracts identified 71 studies for full-text screening. After complete review of the manuscript, 42 were excluded for the following reasons: 2 described technique development; 23 presented an outcome that was not diagnostic confirmation, early detection related, or prognosis; 11 reported detection methods for single pathogens outside the context of BRD; 2 were review papers; 2 had no full-text available; and 2 described only chronic
Implications and limitations
Results of this systematic review enable veterinarians, researchers, and producers to compare the various methods and technologies currently available to confirm and detect BRD and predict detrimental BRD outcome. Economic considerations of methods to confirm and early detect BRD or prognostic methods should always precede investment in commercial feedlots. One study suggested early detection methods need to cost less than CAD 4.06 per steer to improve economic revenues for commercial feedlots
Summary
Numerous methods have been examined to improve BRD diagnosis related to confirmation, early detection, and estimating prognosis. Existing evidence supports the use of HAP to confirm BRD status, but there was limited value for WBC counts and bacteriology in confirming BRD cases. Initial studies using breath analysis, lung ultrasonography, and percutaneous lung biopsy did not provide promising results for BRD confirmation. Early detection of BRD has been successfully performed using IRT, ruminal
References (53)
- et al.
Impact of early versus later fluoroquinolone treatment on the clinical; microbiological and resistance outcomes in a mouse-lung model of Pasteurella multocida infection
Vet Microbiol
(2011) - et al.
Bacterial pathogens of the bovine respiratory disease complex
Vet Clin North Am Food Anim Pract
(2010) - et al.
The application of knowledge synthesis methods in agri-food public health: recent advancements, challenges and opportunities
Prev Vet Med
(2014) - et al.
Comparison of classification algorithms to predict outcomes of feedlot cattle identified and treated for bovine respiratory disease
Comput Electron Agr
(2014) - et al.
Acute phase proteins in naturally occurring respiratory disease of feedlot cattle
Vet Immunol Immunopathol
(2015) - et al.
Early detection of bovine respiratory disease in young bulls using reticulo-rumen temperature boluses
Vet J
(2011) - et al.
The non-invasive and automated detection of bovine respiratory disease onset in receiver calves using infrared thermography
Res Vet Sci
(2012) - et al.
The use of infrared thermography as an early indicator of bovine respiratory disease complex in calves
Res Vet Sci
(2007) - et al.
Nasal isolation of Mannheimia haemolytica and Pasteurella multocida as predictors of respiratory disease in shipped calves
Res Vet Sci
(2015) - et al.
Evaluation of the ruminant complete blood cell count
Vet Clin North Am Food Anim Pract
(2007)
Biological basis of the behavior of sick animals
Neurosci Biobehav Rev
Evaluating the cost implications of a radio frequency identification feeding system for early detection of bovine respiratory disease in feedlot cattle
Prev Vet Med
Feedlot 2011 part IV: health and health management on U.S. feedlots with a capacity of 1,000 or more head
Evaluation of economic and performance outcomes associated with the number of treatments after an initial diagnosis of bovine respiratory disease in commercial feeder cattle
Am J Vet Res
An evaluation of bovine respiratory disease complex in feedlot cattle: impact on performance and carcass traits using treatment records and lung lesion scores
J Anim Sci
Impact of bovine respiratory disease (BRD) from the perspective of the Canadian beef producer
Anim Health Res Rev
Health of finishing steers: effects on performance, carcass traits, and meat tenderness
J Anim Sci
Bayesian estimation of the performance of using clinical observations and harvest lung lesions for diagnosing bovine respiratory disease in post-weaned beef calves
J Vet Diagn Invest
Board-invited review: using behavior to predict and identify ill health in animals
J Anim Sci
Visually undetected fever episodes in newly received beef bulls at a fattening operation: occurrence, duration, and impact on performance
J Anim Sci
Therapeutic and prophylactic effects of some antibiotics on experimental pneumonic pasteurellosis
Can Vet J
A stochastic model to determine the economic value of changing diagnostic test characteristics for identification of cattle for treatment of bovine respiratory disease
J Anim Sci
The monster we don't see: subclinical BRD in beef cattle
Anim Health Res Rev
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement
Open Med
Field results from whisper stethoscope studies
Anim Health Res Rev
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2021, Journal of Dairy ScienceCitation Excerpt :Other general clinical signs of disease reported in the included studies were depression or depressed mental status and decreased feed intake or anorexia. Depression and appetite changes are considered to be early signs of BRD in feedlot calves (Wolfger et al., 2015a,b; Jackson et al., 2016; Toaff-Rosenstein et al., 2016). In dairy calves experimentally infected with Mannheimia haemolytica, the change in feed intake and behavior are early indicators of disease progression (Hixson et al., 2018).
The authors have nothing to disclose.