Veterinary Clinics of North America: Food Animal Practice
Evidence Related to the Use of Ancillary Drugs in Bovine Respiratory Disease (Anti-Inflammatory and Others): Are They Justified or Not?
Section snippets
Material and Methods
After consultation among the current authors, the Patient/Population, Intervention, Comparison, and Outcome of clinical importance (PICO) strategy was used. The clinical question we tried to answer was, In cattle with naturally occurring BRD, are there any beneficial effects of adding an ancillary drug to antimicrobial treatment? Parameters to be evaluated for a beneficial effect were rectal temperature, the relapse rate, failure of treatment, the short- to long-term ADG or feed efficiency, the
Search Process and Identification of Relevant Studies
Only 15 articles met the initial criteria, 14 dealt with AIDs (12 NSAIDs, 1 steroidal anti-inflammatory drug [SAID], and 1 both SAID and NSAID) and 1 with immunomodulators. The reviewing process and extraction of the data are described in Fig. 1. Briefly, 358 different articles were found using the search strategy previously mentioned. Among the 59 articles remaining after title exclusion, 36 were excluded for the following reasons: 2 were studies utilizing an experimental model, 3 were the
Discussion
The main objective of this systematic review was to evaluate ancillary treatments that may be beneficial in the treatment of BRD. Since the etiology of BRD is complex and multifactorial, it is necessary to have well-organized, published RCTs for clinicians to make decisions related to including or excluding ancillary therapies for BRD. The results reported here demonstrate that only 6 RCTs are available in the published literature for the evaluation of ancillary BRD treatment regimens in
Summary
In conclusion, scarce relevant information is actually available on the use of ancillary treatment in BRD other than NSAIDs. However, even studies on NSAIDs lack consistent reliability and validity. Well-designed RCTs of long duration are necessary to support conclusions related to the actual consequences of NSAID treatment. These studies should include short-term data (temperature, clinical improvement, relapse, or failure to treatment) as well as long-term data (productivity parameters,
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The authors have nothing to disclose.