Major articleThe prevalence and influencing factors of methicillin-resistant Staphylococcus aureus carriage in people in contact with livestock: A systematic review
Section snippets
Literature search
Our systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.18 An online search of all published human epidemiologic studies (in English) on the prevalence of MRSA carriage in people in contact with livestock between January 1990 and May 2014 was conducted using the following databases: Pubmed, Medline, Embase, Ovid, and the Cochrane Library. Search terms included Staphylococcus aureus and livestock. Additionally, relevant
Eligible studies
The literature search and study selection process are shown in Figure 1. By reading abstracts and titles, 37 studies were selected for further investigation. After reviewing the full text of the remaining studies, 7 studies26, 27, 28, 29, 30, 31, 32 were excluded for the reasons noted in Figure 1. Three studies were included through manual searches of the relevant journals and reference lists.11, 33, 34 In total, 33 studies were ultimately included in our systematic review.7, 8, 9, 11, 12, 13,
Discussion
There is a lack of worldwide data regarding MRSA prevalence in people in contact with livestock. Ours is the first study systematically reviewing the prevalence of MRSA carriage in people in contact with livestock. Overall, we found a high prevalence of MRSA carriage in people in contact with livestock. Moreover, we found animal contact and intensity of animal contact were significantly related to MRSA carriage.
The prevalence of MRSA in people in contact with livestock (14.2%) was significantly
Conclusions
Our systematic review of observational studies suggests the prevalence of MRSA in people in contact with livestock is much higher than that of the general population. Moreover, animal contact and intensity of animal contact were associated with increased risk of MRSA carriage. Our findings suggest that there may be transmission of MRSA between animals and humans.
References (59)
- et al.
High burden of antimicrobial resistance in Asia
Int J Antimicrob Agents
(2011) - et al.
Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: an international study
Clin Microbiol Infect
(2008) - et al.
Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers
Vet Microbiol
(2008) - et al.
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
Lancet
(2007) - et al.
First reporting of methicillin-resistant Staphylococcus aureus (MRSA) ST398 in an industrial rabbit holding and in farm-related people
Vet Microbiol
(2014) - et al.
High diversity of Staphylococcus aureus and Staphylococcus pseudintermedius lineages and toxigenic traits in healthy pet-owning household members. Underestimating normal household contact?
Comp Immunol Microbiol Infect Dis
(2013) - et al.
MRSA carriage in the equine community: an investigation of horse-caretaker couples
Vet Microbiol
(2013) - et al.
The community prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in older people living in their own homes: implications for treatment, screening and surveillance in the UK
J Hosp Infect
(2004) - et al.
Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis
Clin Infect Dis
(2003) - et al.
Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections
Clin Infect Dis
(2006)
The economic impact of Staphylococcus aureus infection in New York City hospitals
Emerg Infect Dis
National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011
JAMA Intern Med
Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe
Euro Surveill
Methicillin-resistant Staphylococcus aureus (MRSA) strain ST398 is present in midwestern U.S. swine and swine workers
PLoS One
Livestock-associated MRSA ST398 carriage in pig slaughterhouse workers related to quantitative environmental exposure
Occup Environ Med
Community-acquired MRSA and pig-farming
Ann Clin Microbiol Antimicrob
Incidence and characterisation of methicillin-resistant Staphylococcus aureus (MRSA) from nasal colonisation in participants attending a cattle veterinary conference in the UK
PLoS One
Livestock-associated methicillin and multidrug resistant Staphylococcus aureus is present among industrial, not antibiotic-free livestock operation workers in North Carolina
PLoS One
Colonization of butchers with livestock-associated methicillin-resistant Staphylococcus aureus
Zoonoses Public Health
High prevalence of nasal MRSA carriage in slaughterhouse workers in contact with live pigs in The Netherlands
Epidemiol Infect
MRSA-ST398 in livestock farmers and neighbouring residents in a rural area in Germany
Epidemiol Infect
Prevalence, risk factors and genetic diversity of methicillin-resistant Staphylococcus aureus carried by humans and animals across livestock production sectors
J Antimicrob Chemother
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
BMJ
Transformations related to the angular and the square root
Annals of Mathematical Statistics
Probable inference, the law of succession, and statistical inference
J Am Stat Assoc
Quantifying heterogeneity in a meta-analysis
Stat Med
Measuring inconsistency in meta-analyses
BMJ
Operating characteristics of a rank correlation test for publication bias
Biometrics
Bias in meta-analysis detected by a simple, graphical test
BMJ
Cited by (0)
WL and SL contributed equally to this work.
This work was supported by the Natural Science Foundation of Guangdong province (No. S2011010002481), the Innovation Fund of the Department of Education of Guangdong Province (No. 2013KJCX0112), and the Joint Natural Sciences Fund of the Department of Science and Technology and the First Affiliated Hospital of Guangdong Pharmaceutical University (No. GYFYLH201331). The funders had no role in study design, data collection and analysis, and interpretation of the data.
Conflicts of interest: None to report.