Elsevier

Tetrahedron Letters

Volume 47, Issue 47, 20 November 2006, Pages 8205-8207
Tetrahedron Letters

Highly-loaded amphiphilic polyimino resin: quench reagent and solid support for peptide synthesis

https://doi.org/10.1016/j.tetlet.2006.09.131Get rights and content

Abstract

We demonstrate herein that polyimino resin 4a prepared by condensation of α,α′-dichloro-p-xylene, ethylenediamine and tris-(2-aminoethyl)-amine can be successfully exploited as a quench reagent for acids and electrophiles both in aqueous and organic solutions. Scope and limitations of such a resin as a solid support for peptide synthesis were also investigated.

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Acknowledgment

The authors gratefully acknowledge Dr. Florine Cavelier for helpful discussions.

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