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A cross-species approach to disorders affecting brain and behaviour

Nature Reviews Neurology volume 14, pages 677–686 (2018)Cite this article

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Abstract

Structural and functional elements of biological systems are highly conserved across vertebrates. Many neurological and psychiatric conditions affect both humans and animals. A cross-species approach to the study of brain and behaviour can advance our understanding of human disorders via the identification of unrecognized natural models of spontaneous disorders, thus revealing novel factors that increase vulnerability or resilience, and via the assessment of potential therapies. Moreover, diagnostic and therapeutic advances in human neurology and psychiatry can often be adapted for veterinary patients. However, clinical and research collaborations between physicians and veterinarians remain limited, leaving this wealth of comparative information largely untapped. Here, we review pain, cognitive decline syndromes, epilepsy, anxiety and compulsions, autoimmune and infectious encephalitides and mismatch disorders across a range of animal species, looking for novel insights with translational potential. This comparative perspective can help generate novel hypotheses, expand and improve clinical trials and identify natural animal models of disease resistance and vulnerability.

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Fig. 1: Accumulation of amyloid-β in dogs and humans.

Images courtesy of E. Head, University of Kentucky, USA.

Fig. 2: Detection of antineuronal autoantibodies present in human and animal encephalitides.

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Acknowledgements

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Nature Reviews Neurology thanks Á. Pákozdy, C. Rusbridge and T. Sabin for their contribution to the peer review of this work.

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Authors and Affiliations

  1. Department of Neurology, New York University (NYU) Langone Medical Center and NYU School of Medicine, New York, NY, USA

    Orrin Devinsky, Daniel Friedman, Brian Hainline & Thomas Wisniewski

  2. College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

    Jordyn M. Boesch, Sofia Cerda-Gonzalez, Katherine Houpt & Pamela Perry

  3. Department of Child and Adolescent Psychiatry, University of Miami Miller School of Medicine, Miami, FL, USA

    Barbara Coffey

  4. Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Kathryn Davis

  5. Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA

    Daniel Lieberman

  6. Department of Neurology with Experimental Neurology, Charité University Medicine Berlin, Berlin, Germany, and German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany

    Harald Prüss

  7. Brigham and Women’s Hospital, Boston, MA, USA

    Martin A. Samuels

  8. University of California–Los Angeles (UCLA) Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Gary W. Small

  9. Veterinary Neurology and Neurosurgery, The Royal Veterinary College, University of London, London, UK

    Holger Volk

  10. Institute of Virology and Immunology and Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

    Artur Summerfield

  11. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Charles Vite

  12. Department of Ecology and Evolutionary Biology, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Barbara Natterson-Horowitz

Authors
  1. Orrin Devinsky
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  2. Jordyn M. Boesch
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  3. Sofia Cerda-Gonzalez
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  4. Barbara Coffey
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  5. Kathryn Davis
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  6. Daniel Friedman
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  7. Brian Hainline
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  9. Daniel Lieberman
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  10. Pamela Perry
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  11. Harald Prüss
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  12. Martin A. Samuels
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  13. Gary W. Small
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  14. Holger Volk
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  15. Artur Summerfield
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  16. Charles Vite
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  17. Thomas Wisniewski
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  18. Barbara Natterson-Horowitz
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Contributions

All authors contributed to writing the article. O.D. and B.N.-H. reviewed and edited the manuscript before submission.

Corresponding author

Correspondence to Orrin Devinsky.

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Devinsky, O., Boesch, J.M., Cerda-Gonzalez, S. et al. A cross-species approach to disorders affecting brain and behaviour. Nat Rev Neurol 14, 677–686 (2018). https://doi.org/10.1038/s41582-018-0074-z

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